Fluorine-18 labelling of fatty acid esters using exchange resins in gas chromatographic columns

Karim, H. M. A.

Book/Report

FZJ-2018-00331

Fluorine-18 labelling of fatty acid esters using exchange resins in gas chromatographic columns

Karim, H. M. A. (Corresponding author)

1974
Kernforschungsanlage Jülich, Verlag Jülich

Jülich : Kernforschungsanlage Jülich, Verlag, Berichte der Kernforschungsanlage Jülich 1145, 33 p. (1974)

Please use a persistent id in citations: http://hdl.handle.net/2128/16497

Report No.: Juel-1145-NC

Abstract: 1.1. $\underline{Fluorine-18}$Unlike $^{3}$H or $^{14}$C which are generally used for labelling organic molecules, $^{18}$F is a positron emitter ($\beta^{+}$, 0.635 MeV, 97 %) [1] which can be easily detected by 0.511 MeV annihilation $\gamma$-quanta. This radionuclide is very useful in biology, medicine and other scientific disciplines not only because of its short half-life (109.87 $\pm$ 0.12 min) [2] or its mode of decay but also because there is no other longer-lived radionuclide of fluorine. Furthermore, it is a convenient label for organic molecules of biological importance (see below). The optimal physical half-life of a nuclide used to study a physiological phenomenon in a living organism is 0.69 times the elapsed time between administration of the substance and measurement of emitted radiation. As this time is less than a few hours in most medical applications $^{18}$F falls in a class of radionuclides most suitable for this purpose [3]. This nuclide has been extensively used for bone scanning for more than 10 years. The metabolism of $^{18}$F$^{-}$ ions as tracer was investigated by WALLACE-DURBIN [4] in 1954 and this nuclide was first used by BLAU et al [5] for bone scanning. ANBAR [6] applied $^{18}$F$^{-}$ ions to a great variety of problems in biology and medicine, especially to the study of bone physiology. CLARK and SILVESTER [7] used $^{18}$F in their clinical studies and WEBER et al [8] investigated the kinetics of $^{18}$F for bone studies. More than hundred patient scans were performed by LAUGHLIN et al [9] within one year in 1969. The potential medical uses of this nuclide have been pointed out by SILVESTER [10]. [...]

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